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KMID : 0359920080270050606
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Korean Journal of Nephrology
2008 Volume.27 No. 5 p.606 ~ p.610
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An Adult Case of Tubulointerstitial Nephritis and Uveitis Syndrome in Korea
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Kim Soo-Min
Kwon Ghee-Young
Kim Dae-Joong
Lee Jung-Eun
Huh Woo-Sung
Kim Yoon-Goo
Oh Ha-Young
Song Jae-Uk
Choi E-Ryoung
Choi Hee-Joung
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Abstract
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We report a case of adult-onset tubulointerstitial nephritis and uveitis syndrome with Fanconi syndrome. A 31-year-woman presented with fever, anorexia, nausea, general weakness and weight loss for two months. Her initial laboratory findings showed anemia, high serum creatinine, hypouricemia, hypophosphatemia, hypokalemia, glucosuria, and proteinuria. She was diagnosed as having acute tubulointerstitial nephritis by renal biopsy. The etiology of tubulointerstitial nephritis was unclear. She was treated with systemic corticosteroid. Six months later and while the patient was still on systemic corticosteroid (Deflazacort 36 mg), bilateral uveitis developed. Renal function was recovered by systemic corticosteroid and mycophenolic acid. But ocular symptoms relapsed twice despite systemic corticosteroid treatment. The ocular symptoms improved after topical ophthalmic steroid drops and injection. Tubulointerstitial nephritis and uveitis syndrome should be considered in the differential diagnosis of the unexplained tubulointerstitial nephritis. And the need of the steroid treatment also should be considered in the case of adult-onset.
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KEYWORD
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Tubulointerstitial Nephritis, Uveitis, Fanconi syndrome, Steroids
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